I use the mouse-gestures in Firefox, it is one of the key reasons for why I favor Firefox over IE (the two others being adblocking and tabed-browsing). Recently I found out that there is an application that allows you to add mouse-gestures to all applications, it comes with the thought-provoking name "StrokeIt". I immediately found one good use for it, namely to navigate back and forth in VisualStudio. It has not caused me any problems yet (2 days of use), so I feel that I can recommend it.
P.s. I finally gave up on StrokeIt, it was causing some spurious mouse movements that in time became too irritating to tolerate.